Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4615347..4616181 Replicon chromosome
Accession NZ_CP126944
Organism Escherichia coli O1:K1:H7 strain APEC E16002

Toxin (Protein)


Gene name yeeV Uniprot ID B7MK10
Locus tag QQA28_RS22890 Protein ID WP_000854820.1
Coordinates 4615804..4616181 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag QQA28_RS22885 Protein ID WP_001285610.1
Coordinates 4615347..4615715 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA28_RS22845 (4611068) 4611068..4611748 + 681 WP_001278649.1 WYL domain-containing protein -
QQA28_RS22850 (4611899) 4611899..4612576 + 678 WP_001097565.1 hypothetical protein -
QQA28_RS22855 (4612582) 4612582..4612815 + 234 WP_000883181.1 DUF905 family protein -
QQA28_RS22860 (4612905) 4612905..4613723 + 819 WP_001175155.1 DUF932 domain-containing protein -
QQA28_RS22865 (4613749) 4613749..4613889 - 141 WP_000997937.1 hypothetical protein -
QQA28_RS22870 (4613989) 4613989..4614468 + 480 WP_000706978.1 antirestriction protein -
QQA28_RS22875 (4614483) 4614483..4614959 + 477 WP_001186193.1 RadC family protein -
QQA28_RS22880 (4615046) 4615046..4615267 + 222 WP_000692347.1 DUF987 domain-containing protein -
QQA28_RS22885 (4615347) 4615347..4615715 + 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQA28_RS22890 (4615804) 4615804..4616181 + 378 WP_000854820.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QQA28_RS22895 (4616178) 4616178..4616375 + 198 Protein_4488 DUF5983 family protein -
QQA28_RS22900 (4616403) 4616403..4616600 + 198 WP_085949158.1 DUF957 domain-containing protein -
QQA28_RS22905 (4616685) 4616685..4617245 + 561 Protein_4490 DUF4942 domain-containing protein -
QQA28_RS22910 (4618080) 4618080..4619618 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14043.12 Da        Isoelectric Point: 7.8839

>T283254 WP_000854820.1 NZ_CP126944:4615804-4616181 [Escherichia coli O1:K1:H7]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT283254 WP_001285610.1 NZ_CP126944:4615347-4615715 [Escherichia coli O1:K1:H7]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2KXX6

Antitoxin

Source ID Structure

References