Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4559632..4560466 Replicon chromosome
Accession NZ_CP126940
Organism Escherichia coli O2:K1:H7 strain APEC E18055

Toxin (Protein)


Gene name yeeV Uniprot ID B7MK10
Locus tag QQA30_RS22600 Protein ID WP_000854820.1
Coordinates 4560089..4560466 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag QQA30_RS22595 Protein ID WP_001285610.1
Coordinates 4559632..4560000 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQA30_RS22555 (4555353) 4555353..4556033 + 681 WP_001278649.1 WYL domain-containing protein -
QQA30_RS22560 (4556184) 4556184..4556861 + 678 WP_001097565.1 hypothetical protein -
QQA30_RS22565 (4556867) 4556867..4557100 + 234 WP_000883181.1 DUF905 family protein -
QQA30_RS22570 (4557190) 4557190..4558008 + 819 WP_001175155.1 DUF932 domain-containing protein -
QQA30_RS22575 (4558034) 4558034..4558174 - 141 WP_000997937.1 hypothetical protein -
QQA30_RS22580 (4558274) 4558274..4558753 + 480 WP_000706978.1 antirestriction protein -
QQA30_RS22585 (4558768) 4558768..4559244 + 477 WP_001186193.1 RadC family protein -
QQA30_RS22590 (4559331) 4559331..4559552 + 222 WP_000692347.1 DUF987 domain-containing protein -
QQA30_RS22595 (4559632) 4559632..4560000 + 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QQA30_RS22600 (4560089) 4560089..4560466 + 378 WP_000854820.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
QQA30_RS22605 (4560463) 4560463..4560660 + 198 Protein_4428 DUF5983 family protein -
QQA30_RS22610 (4560688) 4560688..4560885 + 198 WP_085949158.1 DUF957 domain-containing protein -
QQA30_RS22615 (4560970) 4560970..4561530 + 561 Protein_4430 DUF4942 domain-containing protein -
QQA30_RS22620 (4562365) 4562365..4563903 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14043.12 Da        Isoelectric Point: 7.8839

>T283185 WP_000854820.1 NZ_CP126940:4560089-4560466 [Escherichia coli O2:K1:H7]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNIILGKHPEVKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT283185 WP_001285610.1 NZ_CP126940:4559632-4560000 [Escherichia coli O2:K1:H7]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2KXX6

Antitoxin

Source ID Structure

References