Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 66840..67399 | Replicon | plasmid pAA-09EL50 |
| Accession | NC_018654 | ||
| Organism | Escherichia coli O104:H4 str. 2009EL-2050 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G4VUF8 |
| Locus tag | O3M_RS27570 | Protein ID | WP_000421273.1 |
| Coordinates | 67124..67399 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0SRR3 |
| Locus tag | O3M_RS27565 | Protein ID | WP_001387467.1 |
| Coordinates | 66840..67124 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| O3M_RS27530 | 61879..62556 | - | 678 | WP_001339397.1 | IS66 family insertion sequence hypothetical protein | - |
| O3M_RS27535 | 62621..62833 | + | 213 | Protein_72 | ANR family transcriptional regulator | - |
| O3M_RS27540 | 63284..64264 | - | 981 | WP_000019427.1 | IS5-like element ISKpn26 family transposase | - |
| O3M_RS27545 | 64545..64799 | + | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
| O3M_RS32190 | 64906..65040 | + | 135 | Protein_75 | protein CopA/IncA | - |
| O3M_RS27550 | 65037..65111 | + | 75 | WP_014966221.1 | RepA leader peptide Tap | - |
| O3M_RS27560 | 65104..65932 | + | 829 | Protein_77 | incFII family plasmid replication initiator RepA | - |
| O3M_RS27565 | 66840..67124 | + | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| O3M_RS27570 | 67124..67399 | + | 276 | WP_000421273.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| O3M_RS27575 | 67405..67736 | + | 332 | Protein_80 | type II toxin-antitoxin system ParD family antitoxin | - |
| O3M_RS27580 | 67852..68013 | + | 162 | WP_001440647.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| O3M_RS27585 | 68136..68261 | + | 126 | WP_032159539.1 | hypothetical protein | - |
| O3M_RS27590 | 68382..69122 | + | 741 | WP_001066951.1 | tyrosine-type recombinase/integrase | - |
| O3M_RS27595 | 69401..70378 | - | 978 | WP_001387465.1 | RepB family plasmid replication initiator protein | - |
| O3M_RS27610 | 71470..71619 | + | 150 | Protein_85 | transposase domain-containing protein | - |
| O3M_RS27615 | 71702..72103 | - | 402 | WP_001392130.1 | type II toxin-antitoxin system VapC family toxin | - |
| O3M_RS27620 | 72127..72357 | - | 231 | WP_001261288.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | aggD / aggC / aggB / aggA / aap/aspU | 1..74213 | 74213 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10765.45 Da Isoelectric Point: 9.9324
>T28305 WP_000421273.1 NC_018654:67124-67399 [Escherichia coli O104:H4 str. 2009EL-2050]
MELKWTSKALSDLSRLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
MELKWTSKALSDLSRLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T28305 NC_018654:67124-67399 [Escherichia coli O104:H4 str. 2009EL-2050]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT28305 WP_001387467.1 NC_018654:66840-67124 [Escherichia coli O104:H4 str. 2009EL-2050]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
Download Length: 285 bp
>AT28305 NC_018654:66840-67124 [Escherichia coli O104:H4 str. 2009EL-2050]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y6H1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y880 |