Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3378902..3379522 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QN087_RS16280 Protein ID WP_001280991.1
Coordinates 3379304..3379522 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6C6Z3Y6
Locus tag QN087_RS16275 Protein ID WP_000344806.1
Coordinates 3378902..3379276 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS16265 (3374041) 3374041..3375234 + 1194 WP_001039204.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QN087_RS16270 (3375257) 3375257..3378406 + 3150 WP_020976763.1 efflux RND transporter permease AcrB -
QN087_RS16275 (3378902) 3378902..3379276 + 375 WP_000344806.1 Hha toxicity modulator TomB Antitoxin
QN087_RS16280 (3379304) 3379304..3379522 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QN087_RS16285 (3379701) 3379701..3380252 + 552 WP_001278793.1 maltose O-acetyltransferase -
QN087_RS16290 (3380370) 3380370..3380840 + 471 Protein_3195 YlaC family protein -
QN087_RS16295 (3380896) 3380896..3381036 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QN087_RS16300 (3381038) 3381038..3381304 - 267 WP_020937098.1 type B 50S ribosomal protein L31 -
QN087_RS16305 (3381529) 3381529..3383079 + 1551 WP_000213140.1 EAL domain-containing protein -
QN087_RS16315 (3383310) 3383310..3383699 + 390 WP_000961288.1 MGMT family protein -
QN087_RS16320 (3383732) 3383732..3384301 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T282756 WP_001280991.1 NZ_CP126323:3379304-3379522 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14425.25 Da        Isoelectric Point: 5.1444

>AT282756 WP_000344806.1 NZ_CP126323:3378902-3379276 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATKANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6Z3Y6

References