Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 196018..196778 Replicon chromosome
Accession NZ_CP126323
Organism Salmonella enterica subsp. enterica strain CY16

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag QN087_RS00920 Protein ID WP_000533909.1
Coordinates 196293..196778 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag QN087_RS00915 Protein ID WP_000965886.1
Coordinates 196018..196305 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN087_RS00895 (191423) 191423..192334 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
QN087_RS00900 (192344) 192344..194413 + 2070 WP_001291748.1 glycine--tRNA ligase subunit beta -
QN087_RS00905 (194803) 194803..195201 + 399 Protein_179 IS3 family transposase -
QN087_RS00910 (195373) 195373..195840 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
QN087_RS00915 (196018) 196018..196305 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
QN087_RS00920 (196293) 196293..196778 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
QN087_RS00925 (197149) 197149..197688 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
QN087_RS00930 (197862) 197862..198074 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
QN087_RS00935 (198362) 198362..198652 - 291 WP_000455790.1 HTH-type transcriptional regulator -
QN087_RS00940 (199091) 199091..199801 + 711 WP_000190524.1 DUF3053 domain-containing protein -
QN087_RS00945 (199851) 199851..200813 - 963 WP_000804673.1 glyoxylate/hydroxypyruvate reductase GhrB -
QN087_RS00950 (201032) 201032..201694 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T282745 WP_000533909.1 NZ_CP126323:196293-196778 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT282745 WP_000965886.1 NZ_CP126323:196018-196305 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References