Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2447227..2447887 Replicon chromosome
Accession NZ_CP126166
Organism Salmonella enterica subsp. enterica strain CRSE-01

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NED09_RS11745 Protein ID WP_000244756.1
Coordinates 2447474..2447887 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NED09_RS11740 Protein ID WP_000351186.1
Coordinates 2447227..2447493 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NED09_RS11720 (2443156) 2443156..2444589 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NED09_RS11725 (2444747) 2444747..2445058 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NED09_RS11730 (2445222) 2445222..2445881 + 660 WP_000250289.1 hemolysin III family protein -
NED09_RS11735 (2445997) 2445997..2446977 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NED09_RS11740 (2447227) 2447227..2447493 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NED09_RS11745 (2447474) 2447474..2447887 + 414 WP_000244756.1 protein YgfX Toxin
NED09_RS11750 (2447940) 2447940..2448461 - 522 WP_001055885.1 flavodoxin FldB -
NED09_RS11755 (2448574) 2448574..2449470 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NED09_RS11760 (2449494) 2449494..2450207 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NED09_RS11765 (2450213) 2450213..2451946 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T282712 WP_000244756.1 NZ_CP126166:2447474-2447887 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT282712 WP_000351186.1 NZ_CP126166:2447227-2447493 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References