Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4697453..4698055 Replicon chromosome
Accession NZ_CP126138
Organism Salmonella enterica subsp. enterica serovar Kottbus strain DSK01

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag QNM33_RS22935 Protein ID WP_001159630.1
Coordinates 4697744..4698055 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QNM33_RS22930 Protein ID WP_000362050.1
Coordinates 4697453..4697743 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM33_RS22915 (4694946) 4694946..4695848 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
QNM33_RS22920 (4695845) 4695845..4696480 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QNM33_RS22925 (4696477) 4696477..4697406 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
QNM33_RS22930 (4697453) 4697453..4697743 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QNM33_RS22935 (4697744) 4697744..4698055 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QNM33_RS22940 (4698273) 4698273..4699202 + 930 WP_001127703.1 alpha/beta hydrolase -
QNM33_RS22945 (4699288) 4699288..4699599 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
QNM33_RS22950 (4699596) 4699596..4700042 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
QNM33_RS22955 (4700057) 4700057..4700998 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QNM33_RS22960 (4701043) 4701043..4701480 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
QNM33_RS22965 (4701477) 4701477..4702349 - 873 WP_000921427.1 virulence factor BrkB family protein -
QNM33_RS22970 (4702343) 4702343..4702942 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T282670 WP_001159630.1 NZ_CP126138:c4698055-4697744 [Salmonella enterica subsp. enterica serovar Kottbus]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT282670 WP_000362050.1 NZ_CP126138:c4697743-4697453 [Salmonella enterica subsp. enterica serovar Kottbus]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References