Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4377205..4377986 | Replicon | chromosome |
| Accession | NZ_CP126138 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kottbus strain DSK01 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | QNM33_RS21510 | Protein ID | WP_000626099.1 |
| Coordinates | 4377205..4377696 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | QNM33_RS21515 | Protein ID | WP_001110452.1 |
| Coordinates | 4377693..4377986 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QNM33_RS21475 (4373200) | 4373200..4373775 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| QNM33_RS21485 (4374046) | 4374046..4374123 | - | 78 | Protein_4199 | helix-turn-helix domain-containing protein | - |
| QNM33_RS21490 (4374214) | 4374214..4374546 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| QNM33_RS21495 (4374618) | 4374618..4374995 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| QNM33_RS21500 (4376028) | 4376028..4376102 | + | 75 | Protein_4202 | porin family protein | - |
| QNM33_RS21505 (4376205) | 4376205..4376957 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| QNM33_RS21510 (4377205) | 4377205..4377696 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| QNM33_RS21515 (4377693) | 4377693..4377986 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| QNM33_RS21520 (4378303) | 4378303..4378524 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| QNM33_RS21525 (4378789) | 4378789..4379664 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| QNM33_RS21530 (4379661) | 4379661..4379948 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| QNM33_RS21535 (4379971) | 4379971..4380186 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| QNM33_RS21540 (4380194) | 4380194..4380463 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| QNM33_RS21545 (4380757) | 4380757..4381662 | - | 906 | Protein_4211 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T282669 WP_000626099.1 NZ_CP126138:c4377696-4377205 [Salmonella enterica subsp. enterica serovar Kottbus]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT282669 WP_001110452.1 NZ_CP126138:c4377986-4377693 [Salmonella enterica subsp. enterica serovar Kottbus]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |