Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4175556..4177179 Replicon chromosome
Accession NZ_CP126138
Organism Salmonella enterica subsp. enterica serovar Kottbus strain DSK01

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag QNM33_RS20460 Protein ID WP_000088046.1
Coordinates 4175854..4177179 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag QNM33_RS20455 Protein ID WP_024136327.1
Coordinates 4175556..4175849 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QNM33_RS20425 (4171428) 4171428..4172669 + 1242 WP_001053338.1 VWA domain-containing protein -
QNM33_RS20430 (4172760) 4172760..4172891 + 132 WP_000374059.1 hypothetical protein -
QNM33_RS20435 (4173232) 4173232..4173513 - 282 WP_000077926.1 hypothetical protein -
QNM33_RS20440 (4173563) 4173563..4173754 - 192 WP_000398480.1 hypothetical protein -
QNM33_RS20445 (4173846) 4173846..4174187 - 342 WP_001151575.1 hypothetical protein -
QNM33_RS20450 (4174521) 4174521..4174952 + 432 WP_011152969.1 hypothetical protein -
QNM33_RS20455 (4175556) 4175556..4175849 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
QNM33_RS20460 (4175854) 4175854..4177179 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
QNM33_RS20465 (4177240) 4177240..4177446 + 207 WP_000134171.1 hypothetical protein -
QNM33_RS20470 (4177548) 4177548..4177958 + 411 WP_000985911.1 hypothetical protein -
QNM33_RS20475 (4177971) 4177971..4178660 + 690 WP_225522439.1 HNH endonuclease signature motif containing protein -
QNM33_RS20480 (4178694) 4178694..4179397 - 704 Protein_4003 IS6-like element IS26 family transposase -
QNM33_RS20485 (4179460) 4179460..4179930 + 471 Protein_4004 recombinase family protein -
QNM33_RS20490 (4179995) 4179995..4181124 + 1130 WP_085959879.1 IS3-like element IS1133 family transposase -
QNM33_RS20495 (4181231) 4181231..4182034 + 804 WP_024261901.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aph(3'')-Ib / aph(6)-Id / blaTEM-1B / tet(A) - 4173232..4209277 36045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T282667 WP_000088046.1 NZ_CP126138:4175854-4177179 [Salmonella enterica subsp. enterica serovar Kottbus]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT282667 WP_024136327.1 NZ_CP126138:4175556-4175849 [Salmonella enterica subsp. enterica serovar Kottbus]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References