Detailed information of TA system TA028247

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 354509..355088
• Replicon: chromosome
• Accession: NC_018608
• Organism: Staphylococcus aureus 08BA02176

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: C248_RS01595
• Protein ID: WP_001025401.1
• Coordinates: 354509..354754 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	354723..355088 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C248_RS01540	350035..350181	-	147	WP_001013104.1	hypothetical protein	-
C248_RS01545	350411..350995	-	585	WP_000825948.1	hypothetical protein	-
C248_RS01550	351013..351474	-	462	WP_000525004.1	hypothetical protein	-
C248_RS01555	351487..351801	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
C248_RS01560	351953..352189	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
C248_RS01565	352203..352979	+	777	WP_001148544.1	Rha family transcriptional regulator	-
C248_RS01570	353008..353151	+	144	WP_000939498.1	hypothetical protein	-
C248_RS01575	353141..353350	-	210	WP_000642492.1	hypothetical protein	-
C248_RS14845	353406..353555	+	150	WP_000771849.1	hypothetical protein	-
C248_RS01580	353596..353808	-	213	WP_000362644.1	hypothetical protein	-
C248_RS01585	353878..354075	+	198	WP_001148860.1	hypothetical protein	-
C248_RS01590	354062..354442	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
C248_RS01595	354509..354754	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
C248_RS01600	354723..355088	-	366	WP_001128432.1	hypothetical protein	Antitoxin
C248_RS01605	355143..355358	+	216	WP_001097552.1	hypothetical protein	-
C248_RS01610	355383..355646	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
C248_RS01615	355659..355820	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
C248_RS01620	355899..356222	+	324	WP_000175000.1	hypothetical protein	-
C248_RS01625	356237..356599	+	363	WP_000985986.1	hypothetical protein	-
C248_RS01630	356596..357762	+	1167	WP_000762545.1	DUF2800 domain-containing protein	-
C248_RS01635	357788..358345	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	348093..392677	44584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T28247 WP_001025401.1 NC_018608:354509-354754 [Staphylococcus aureus 08BA02176]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T28247 NC_018608:354509-354754 [Staphylococcus aureus 08BA02176]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT28247 NC_018608:c355088-354723 [Staphylococcus aureus 08BA02176]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAAAACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin