Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3888215..3888812 Replicon chromosome
Accession NZ_CP125734
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag QMW18_RS18910 Protein ID WP_004893639.1
Coordinates 3888495..3888812 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag QMW18_RS18905 Protein ID WP_004142561.1
Coordinates 3888215..3888502 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS18875 (QMW18_18875) 3884295..3884543 + 249 WP_002893037.1 DUF1158 domain-containing protein -
QMW18_RS18880 (QMW18_18880) 3884561..3884902 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QMW18_RS18885 (QMW18_18885) 3884933..3886048 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
QMW18_RS18890 (QMW18_18890) 3886228..3886809 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
QMW18_RS18895 (QMW18_18895) 3886809..3887177 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
QMW18_RS18900 (QMW18_18900) 3887297..3887950 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
QMW18_RS18905 (QMW18_18905) 3888215..3888502 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
QMW18_RS18910 (QMW18_18910) 3888495..3888812 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMW18_RS18915 (QMW18_18915) 3888997..3890040 - 1044 WP_004893645.1 DUF2157 domain-containing protein -
QMW18_RS18920 (QMW18_18920) 3890706..3891572 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
QMW18_RS18925 (QMW18_18925) 3891681..3893108 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T282326 WP_004893639.1 NZ_CP125734:c3888812-3888495 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT282326 WP_004142561.1 NZ_CP125734:c3888502-3888215 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References