Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3160419..3160967 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag O3Q54_RS15085 Protein ID WP_003414602.1
Coordinates 3160704..3160967 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag O3Q54_RS15080 Protein ID WP_003414599.1
Coordinates 3160419..3160700 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Q54_RS15055 (O3Q54_15055) 3156042..3156899 - 858 WP_003899513.1 type I methionyl aminopeptidase -
O3Q54_RS15060 (O3Q54_15060) 3156941..3157525 - 585 WP_003899514.1 DUF1707 domain-containing protein -
O3Q54_RS15065 (O3Q54_15065) 3157629..3157877 + 249 WP_003913411.1 antitoxin VapB23 -
O3Q54_RS15070 (O3Q54_15070) 3157874..3158254 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
O3Q54_RS15075 (O3Q54_15075) 3158336..3160147 - 1812 WP_003906921.1 penicillin-binding protein -
O3Q54_RS15080 (O3Q54_15080) 3160419..3160700 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
O3Q54_RS15085 (O3Q54_15085) 3160704..3160967 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3Q54_RS15090 (O3Q54_15090) 3161340..3162194 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
O3Q54_RS15095 (O3Q54_15095) 3162250..3163413 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
O3Q54_RS15100 (O3Q54_15100) 3163430..3164644 - 1215 WP_003899518.1 zinc metalloprotease Rip -
O3Q54_RS15105 (O3Q54_15105) 3164652..3165893 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T282215 WP_003414602.1 NZ_CP125620:3160704-3160967 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT282215 WP_003414599.1 NZ_CP125620:3160419-3160700 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References