Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4488445..4489047 Replicon chromosome
Accession NZ_CP125220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain sm140

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag QK897_RS21810 Protein ID WP_001159635.1
Coordinates 4488736..4489047 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QK897_RS21805 Protein ID WP_000362050.1
Coordinates 4488445..4488735 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QK897_RS21790 (4485938) 4485938..4486840 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
QK897_RS21795 (4486837) 4486837..4487472 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QK897_RS21800 (4487469) 4487469..4488398 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
QK897_RS21805 (4488445) 4488445..4488735 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QK897_RS21810 (4488736) 4488736..4489047 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QK897_RS21815 (4489265) 4489265..4490194 + 930 WP_001127705.1 alpha/beta hydrolase -
QK897_RS21820 (4490280) 4490280..4490591 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
QK897_RS21825 (4490588) 4490588..4491034 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
QK897_RS21830 (4491049) 4491049..4491990 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QK897_RS21835 (4492035) 4492035..4492472 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
QK897_RS21840 (4492469) 4492469..4493341 - 873 WP_000921423.1 virulence factor BrkB family protein -
QK897_RS21845 (4493335) 4493335..4493934 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T281940 WP_001159635.1 NZ_CP125220:c4489047-4488736 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT281940 WP_000362050.1 NZ_CP125220:c4488735-4488445 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References