281915

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1214..1688 Replicon plasmid pBAK085e
Accession NZ_CP125093
Organism Klebsiella pneumoniae strain BAK085

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag QJS47_RS27855 Protein ID WP_004197762.1
Coordinates 1422..1688 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag QJS47_RS27850 Protein ID WP_000879771.1
Coordinates 1214..1438 (+) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS47_RS27840 (QJS47_27840) 335..547 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
QJS47_RS27845 (QJS47_27845) 923..1051 - 129 WP_000523570.1 hypothetical protein -
QJS47_RS27850 (QJS47_27850) 1214..1438 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
QJS47_RS27855 (QJS47_27855) 1422..1688 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJS47_RS27860 (QJS47_27860) 1758..2108 - 351 WP_004197756.1 hypothetical protein -
QJS47_RS27865 (QJS47_27865) 2174..2719 - 546 WP_023317533.1 hypothetical protein -
QJS47_RS27870 (QJS47_27870) 2745..3071 - 327 WP_050516389.1 hypothetical protein -
QJS47_RS27875 (QJS47_27875) 4227..4403 + 177 WP_004197757.1 hypothetical protein -
QJS47_RS27880 (QJS47_27880) 4393..4737 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
QJS47_RS27885 (QJS47_27885) 4919..5164 - 246 WP_032433971.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-87)

Antitoxin

(4-45)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T281915 WP_004197762.1 NZ_CP125093:1422-1688 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp


Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT281915 WP_000879771.1 NZ_CP125093:1214-1438 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References