Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1374181..1374824 Replicon chromosome
Accession NC_018289
Organism Mycobacterium smegmatis str. MC2 155

Toxin (Protein)


Gene name vapC Uniprot ID A0A8B4QHE7
Locus tag MSMEI_RS06355 Protein ID WP_011727564.1
Coordinates 1374435..1374824 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0QRY5
Locus tag MSMEI_RS06350 Protein ID WP_003892665.1
Coordinates 1374181..1374435 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSMEI_RS06340 1369623..1372994 + 3372 WP_162139587.1 AAA family ATPase -
MSMEI_RS06345 1372991..1374160 + 1170 WP_011727563.1 DUF3322 and DUF2220 domain-containing protein -
MSMEI_RS06350 1374181..1374435 + 255 WP_003892665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MSMEI_RS06355 1374435..1374824 + 390 WP_011727564.1 type II toxin-antitoxin system VapC family toxin Toxin
MSMEI_RS06360 1374843..1377248 - 2406 WP_011727565.1 SEC-C domain-containing protein -
MSMEI_RS06365 1377270..1379030 - 1761 WP_011727566.1 sulfatase-like hydrolase/transferase -
MSMEI_RS06370 1379027..1379464 - 438 WP_011727567.1 SRPBCC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-123)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13909.73 Da        Isoelectric Point: 4.7222

>T28141 WP_011727564.1 NC_018289:1374435-1374824 [Mycolicibacterium smegmatis MC2 155]
MVIDTSALVAILTDEPDAELLEGAVADDPVRTMSTASYLETAIVIESRFGEPGGRELDLWLHRASVALVAVDADQADAAR
LAYRRYGKGRHRAGLNYGDCFSYALAKVSGQPLLFKGEAFRLTDVAAVH

Download         Length: 390 bp

>T28141 NC_018289:1374435-1374824 [Mycolicibacterium smegmatis MC2 155]
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9279.72 Da        Isoelectric Point: 8.0238

>AT28141 WP_003892665.1 NC_018289:1374181-1374435 [Mycolicibacterium smegmatis MC2 155]
MALSIKHPEADRLARELAARTGETLTEAVVMALRERLARTVGRTQVVPLREELAAIRRRCAALPVLDDRTAESILGYDDR
GLPS

Download         Length: 255 bp

>AT28141 NC_018289:1374181-1374435 [Mycolicibacterium smegmatis MC2 155]
ATGGCTCTAAGCATCAAACACCCGGAAGCCGACCGGCTGGCCAGAGAGCTAGCGGCACGTACGGGGGAGACACTGACCGA
GGCGGTGGTGATGGCACTGCGGGAGCGACTGGCGCGCACTGTCGGCCGCACTCAGGTCGTTCCGCTTCGTGAGGAACTCG
CCGCGATCCGTCGTCGCTGCGCAGCCCTACCGGTGTTGGACGACCGGACAGCCGAATCGATCCTGGGCTACGACGACCGC
GGTCTGCCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHE7

Antitoxin

Source ID Structure
AlphaFold DB A0QRY5

References