Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 1366950..1367536 Replicon chromosome
Accession NC_018289
Organism Mycobacterium smegmatis str. MC2 155

Toxin (Protein)


Gene name doc Uniprot ID A0A8B4QHV5
Locus tag MSMEI_RS06325 Protein ID WP_011727560.1
Coordinates 1367144..1367536 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2U9PKT9
Locus tag MSMEI_RS06320 Protein ID WP_011727559.1
Coordinates 1366950..1367147 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSMEI_RS06295 1361983..1363461 - 1479 WP_011727554.1 ADP-ribosylglycohydrolase family protein -
MSMEI_RS06300 1363650..1363991 - 342 WP_011727555.1 DUF732 domain-containing protein -
MSMEI_RS06305 1364051..1365178 - 1128 WP_011727556.1 SMP-30/gluconolactonase/LRE family protein -
MSMEI_RS06310 1365359..1366438 - 1080 WP_011727557.1 HNH endonuclease -
MSMEI_RS06315 1366506..1366802 + 297 WP_011727558.1 nucleoside triphosphate pyrophosphohydrolase -
MSMEI_RS06320 1366950..1367147 + 198 WP_011727559.1 type II toxin-antitoxin system antitoxin Phd Antitoxin
MSMEI_RS06325 1367144..1367536 + 393 WP_011727560.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MSMEI_RS06330 1367613..1369043 + 1431 WP_003892661.1 DUF3375 domain-containing protein -
MSMEI_RS06335 1369040..1369615 + 576 Protein_1244 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(49-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13939.57 Da        Isoelectric Point: 4.2481

>T28140 WP_011727560.1 NC_018289:1367144-1367536 [Mycolicibacterium smegmatis MC2 155]
VTEYLDREDVLTAGSIAFGGELKVRDYGLLDAAVARPQATVYGVDAYPRLWDKAAALLQSLARNHALVDGNKRTAWAAAW
TFLHINGVQLAADFDVDRAEDLMNEVATRDCDLDSIAAELAGFAAAAQTG

Download         Length: 393 bp

>T28140 NC_018289:1367144-1367536 [Mycolicibacterium smegmatis MC2 155]
GTGACCGAGTACCTCGACCGCGAGGACGTGCTCACCGCGGGATCGATCGCTTTTGGCGGCGAGCTGAAGGTGCGGGACTA
CGGACTGCTCGACGCTGCGGTTGCCCGCCCGCAGGCCACGGTGTATGGCGTGGATGCGTACCCGCGGCTGTGGGACAAGG
CCGCTGCGTTGTTGCAGTCCCTGGCGCGGAACCATGCGCTGGTCGACGGTAACAAGCGCACTGCGTGGGCTGCGGCATGG
ACATTTCTGCACATCAACGGTGTACAGCTGGCGGCTGATTTCGATGTCGATCGCGCGGAGGACCTCATGAACGAGGTGGC
CACCCGTGACTGCGACCTGGATTCCATCGCCGCCGAGCTGGCCGGTTTCGCCGCTGCTGCGCAGACGGGGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7276.30 Da        Isoelectric Point: 8.9353

>AT28140 WP_011727559.1 NC_018289:1366950-1367147 [Mycolicibacterium smegmatis MC2 155]
MPSLNIDFDEAEMEQIRAAARADDLSLKKFAHAAVMERASAHKRRVAEAARLVAERSAELNRRLA

Download         Length: 198 bp

>AT28140 NC_018289:1366950-1367147 [Mycolicibacterium smegmatis MC2 155]
ATGCCGTCGCTGAACATCGACTTCGACGAAGCCGAGATGGAACAGATCCGCGCTGCTGCCCGGGCGGATGACCTGTCGCT
GAAGAAGTTCGCGCACGCCGCCGTGATGGAGCGTGCCAGCGCGCACAAGCGCAGGGTCGCCGAGGCGGCGCGTCTGGTCG
CTGAGCGTTCGGCTGAGCTCAACCGCCGCTTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4QHV5

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9PKT9

References