Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4132860..4133514 Replicon chromosome
Accession NZ_CP124809
Organism Citrobacter freundii strain CF13

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag QLG16_RS20035 Protein ID WP_003026936.1
Coordinates 4132860..4133267 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag QLG16_RS20040 Protein ID WP_003026938.1
Coordinates 4133248..4133514 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG16_RS20015 (4128808) 4128808..4130541 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
QLG16_RS20020 (4130547) 4130547..4131260 - 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QLG16_RS20025 (4131284) 4131284..4132180 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
QLG16_RS20030 (4132294) 4132294..4132815 + 522 WP_003026933.1 flavodoxin FldB -
QLG16_RS20035 (4132860) 4132860..4133267 - 408 WP_003026936.1 protein YgfX Toxin
QLG16_RS20040 (4133248) 4133248..4133514 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
QLG16_RS20045 (4133771) 4133771..4134751 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
QLG16_RS20050 (4134845) 4134845..4135504 - 660 WP_003838267.1 hemolysin III family protein -
QLG16_RS20055 (4135667) 4135667..4135978 - 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
QLG16_RS20060 (4136031) 4136031..4136759 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
QLG16_RS20065 (4136880) 4136880..4138313 + 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T281250 WP_003026936.1 NZ_CP124809:c4133267-4132860 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT281250 WP_003026938.1 NZ_CP124809:c4133514-4133248 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References