Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 29681..30324 Replicon plasmid unnamed1
Accession NZ_CP124805
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag QLG20_RS27305 Protein ID WP_001044770.1
Coordinates 29908..30324 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag QLG20_RS27300 Protein ID WP_001261282.1
Coordinates 29681..29911 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS27280 (QLG20_27270) 25746..27119 + 1374 WP_282676415.1 hypothetical protein -
QLG20_RS27285 (QLG20_27275) 27304..28632 + 1329 WP_004206607.1 nucleotidyltransferase -
QLG20_RS27290 (QLG20_27280) 28640..29215 + 576 WP_004206608.1 SLATT domain-containing protein -
QLG20_RS27295 (QLG20_27285) 29482..29724 - 243 Protein_33 hypothetical protein -
QLG20_RS27300 (QLG20_27290) 29681..29911 + 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QLG20_RS27305 (QLG20_27295) 29908..30324 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
QLG20_RS27310 (QLG20_27300) 30398..31960 + 1563 WP_282676416.1 AAA family ATPase -
QLG20_RS27315 (QLG20_27305) 31945..32967 + 1023 WP_000361404.1 helicase UvrD -
QLG20_RS27320 (QLG20_27310) 33511..34419 + 909 WP_032426221.1 HNH endonuclease -
QLG20_RS27325 (QLG20_27315) 34605..34955 - 351 WP_004187110.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..174299 174299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T281237 WP_001044770.1 NZ_CP124805:29908-30324 [Klebsiella variicola]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT281237 WP_001261282.1 NZ_CP124805:29681-29911 [Klebsiella variicola]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References