Detailed information of TA system TA281235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5142790..5144471
• Replicon: chromosome
• Accession: NZ_CP124804
• Organism: Klebsiella variicola strain J57

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: QLG20_RS25025
• Protein ID: WP_124037343.1
• Coordinates: 5142790..5143707 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A0B7GCX3
• Locus tag: QLG20_RS25030
• Protein ID: WP_008807257.1
• Coordinates: 5143713..5144471 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLG20_RS25005 (QLG20_24995)	5138096..5139616	+	1521	WP_022065801.1	sugar ABC transporter ATP-binding protein	-
QLG20_RS25010 (QLG20_25000)	5139613..5140611	+	999	WP_002885172.1	ribose ABC transporter permease	-
QLG20_RS25015 (QLG20_25005)	5140642..5141583	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
QLG20_RS25020 (QLG20_25010)	5141658..5142665	+	1008	WP_022065799.1	carbohydrate kinase family protein	-
QLG20_RS25025 (QLG20_25015)	5142790..5143707	-	918	WP_124037343.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QLG20_RS25030 (QLG20_25020)	5143713..5144471	-	759	WP_008807257.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
QLG20_RS25035 (QLG20_25025)	5144556..5145284	-	729	WP_008807258.1	response regulator transcription factor	-
QLG20_RS25040 (QLG20_25030)	5145557..5147704	+	2148	WP_124037345.1	formate dehydrogenase subunit alpha	-
QLG20_RS25045 (QLG20_25035)	5148322..5149008	+	687	WP_008807260.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34776.13 Da
• Isoelectric Point: 5.7844

>T281235 WP_124037343.1 NZ_CP124804:c5143707-5142790 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPRESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28653.01 Da
• Isoelectric Point: 10.1988

>AT281235 WP_008807257.1 NZ_CP124804:c5144471-5143713 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A0A0B7GCX3