Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2799507..2801101 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QLG20_RS13820 Protein ID WP_104458799.1
Coordinates 2799507..2800835 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag QLG20_RS13825 Protein ID WP_008804920.1
Coordinates 2800835..2801101 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS13805 (QLG20_13795) 2795740..2796744 + 1005 WP_124038024.1 fimbrial protein -
QLG20_RS13810 (QLG20_13800) 2796877..2798169 + 1293 WP_124038025.1 glycoside hydrolase family 10 protein -
QLG20_RS13815 (QLG20_13805) 2798304..2799308 + 1005 WP_001567384.1 IS110-like element IS4321 family transposase -
QLG20_RS13820 (QLG20_13810) 2799507..2800835 - 1329 WP_104458799.1 type II toxin-antitoxin system HipA family toxin Toxin
QLG20_RS13825 (QLG20_13815) 2800835..2801101 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QLG20_RS13830 (QLG20_13820) 2801609..2801935 - 327 WP_124038026.1 hydroxyisourate hydrolase -
QLG20_RS13835 (QLG20_13825) 2801932..2802432 - 501 WP_023297604.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QLG20_RS13840 (QLG20_13830) 2802410..2803789 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
QLG20_RS13845 (QLG20_13835) 2804135..2805289 + 1155 WP_124038027.1 FAD-dependent urate hydroxylase HpxO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2798304..2799308 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49012.36 Da        Isoelectric Point: 7.2497

>T281231 WP_104458799.1 NZ_CP124804:c2800835-2799507 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITESMVTPVFATPILTTSWLA

Download         Length: 1329 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT281231 WP_008804920.1 NZ_CP124804:c2801101-2800835 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References