Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1620079..1621076 Replicon chromosome
Accession NZ_CP124804
Organism Klebsiella variicola strain J57

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QLG20_RS07960 Protein ID WP_229531768.1
Coordinates 1620522..1621076 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag QLG20_RS07955 Protein ID WP_012541033.1
Coordinates 1620079..1620525 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLG20_RS07940 (QLG20_07935) 1616374..1617372 + 999 WP_124037773.1 galactose/glucose ABC transporter substrate-binding protein MglB -
QLG20_RS07945 (QLG20_07940) 1617491..1619011 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
QLG20_RS07950 (QLG20_07945) 1619027..1620037 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
QLG20_RS07955 (QLG20_07950) 1620079..1620525 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
QLG20_RS07960 (QLG20_07955) 1620522..1621076 - 555 WP_229531768.1 HipA domain-containing protein Toxin
QLG20_RS07965 (QLG20_07960) 1621105..1621626 - 522 WP_022064813.1 hypothetical protein -
QLG20_RS07970 (QLG20_07965) 1621741..1622472 - 732 WP_008804033.1 outer membrane permeability protein SanA -
QLG20_RS07975 (QLG20_07970) 1622509..1622727 - 219 WP_048271928.1 hypothetical protein -
QLG20_RS07980 (QLG20_07975) 1622749..1623633 - 885 WP_049139047.1 cytidine deaminase -
QLG20_RS07985 (QLG20_07980) 1623762..1624457 - 696 WP_124037774.1 CidB/LrgB family autolysis modulator -
QLG20_RS07990 (QLG20_07985) 1624447..1624851 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20710.03 Da        Isoelectric Point: 5.7891

>T281225 WP_229531768.1 NZ_CP124804:c1621076-1620522 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT281225 WP_012541033.1 NZ_CP124804:c1620525-1620079 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References