Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 550896..551549 Replicon chromosome
Accession NZ_CP124750
Organism Serratia sp. K-M0706

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SSARUM_RS02525 Protein ID WP_060430834.1
Coordinates 550896..551246 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A5C7DBM3
Locus tag SSARUM_RS02530 Protein ID WP_019453270.1
Coordinates 551250..551549 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSARUM_RS02495 (SSARUM_000499) 546161..546850 - 690 WP_060430826.1 trehalose-6-phosphate synthase -
SSARUM_RS02500 (SSARUM_000500) 546863..547273 - 411 WP_060430828.1 GNAT family N-acetyltransferase -
SSARUM_RS02505 (SSARUM_000501) 547302..548672 - 1371 WP_041037742.1 glutamine synthetase family protein -
SSARUM_RS02510 (SSARUM_000502) 548918..549235 + 318 WP_041037744.1 hypothetical protein -
SSARUM_RS02515 (SSARUM_000503) 549226..549621 - 396 WP_060430830.1 hypothetical protein -
SSARUM_RS02520 (SSARUM_000504) 549621..550625 - 1005 WP_060430832.1 hypothetical protein -
SSARUM_RS02525 (SSARUM_000505) 550896..551246 + 351 WP_060430834.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSARUM_RS02530 (SSARUM_000506) 551250..551549 + 300 WP_019453270.1 XRE family transcriptional regulator Antitoxin
SSARUM_RS02535 (SSARUM_000507) 551539..552456 - 918 WP_060430836.1 LysR family transcriptional regulator -
SSARUM_RS02540 (SSARUM_000508) 552625..553323 + 699 WP_060430838.1 CoA transferase subunit A -
SSARUM_RS02545 (SSARUM_000509) 553335..553988 + 654 WP_060430840.1 CoA transferase subunit B -
SSARUM_RS02550 (SSARUM_000510) 554002..555186 + 1185 WP_060430842.1 acetyl-CoA C-acetyltransferase -
SSARUM_RS02555 (SSARUM_000511) 555205..556128 + 924 WP_039567560.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13526.73 Da        Isoelectric Point: 8.2699

>T281189 WP_060430834.1 NZ_CP124750:550896-551246 [Serratia sp. K-M0706]
MWTVMTTEEFDRWLCEQDESTQEKVLAALVMLERAGPSLRRPFVDVLKGSLHSNMKELRIQHKGRPIRAFFAFDPARQAI
VLCAGDKTGNEKRFYKVMLSIADAQFTQYLMCYFKE

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11013.71 Da        Isoelectric Point: 7.3207

>AT281189 WP_019453270.1 NZ_CP124750:551250-551549 [Serratia sp. K-M0706]
MSTLKQLLASRTPESRRRIEEMAEEMLFEAHLHQLREALNISQQELAKTLGISQPSVAAIEGRGNELKISTLKRYVEAMG
GTLRLDVELPGGKHVGFTV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7DBM3

References