Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3971368..3972588 | Replicon | chromosome |
Accession | NZ_CP124651 | ||
Organism | Pseudomonas aeruginosa strain 2020CK-00217 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
Locus tag | P7I79_RS18470 | Protein ID | WP_003110488.1 |
Coordinates | 3972010..3972588 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | P7I79_RS18465 | Protein ID | WP_003088112.1 |
Coordinates | 3971368..3971922 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
P7I79_RS18440 (P7I79_18440) | 3966936..3967487 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
P7I79_RS18445 (P7I79_18445) | 3967484..3967882 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
P7I79_RS18450 (P7I79_18450) | 3967895..3968218 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
P7I79_RS18455 (P7I79_18455) | 3968549..3969010 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
P7I79_RS18460 (P7I79_18460) | 3969015..3971210 | + | 2196 | WP_023095788.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
P7I79_RS18465 (P7I79_18465) | 3971368..3971922 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
P7I79_RS18470 (P7I79_18470) | 3972010..3972588 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
P7I79_RS18475 (P7I79_18475) | 3972698..3973885 | - | 1188 | WP_003088106.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
P7I79_RS18480 (P7I79_18480) | 3973875..3976046 | - | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
P7I79_RS18485 (P7I79_18485) | 3976036..3977313 | - | 1278 | WP_003088104.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T280955 WP_003110488.1 NZ_CP124651:3972010-3972588 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT280955 WP_003088112.1 NZ_CP124651:3971368-3971922 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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