Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5860774..5861369 Replicon chromosome
Accession NZ_CP124600
Organism Pseudomonas aeruginosa strain Li010

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QIU11_RS27890 Protein ID WP_003113526.1
Coordinates 5861091..5861369 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QIU11_RS27885 Protein ID WP_003113527.1
Coordinates 5860774..5861079 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIU11_RS27860 (QIU11_27860) 5855786..5856058 - 273 WP_003115921.1 hypothetical protein -
QIU11_RS27865 (QIU11_27865) 5856833..5858719 + 1887 WP_071567561.1 ATP-binding protein -
QIU11_RS27870 (QIU11_27870) 5858898..5859170 + 273 WP_071550096.1 DNA-binding protein -
QIU11_RS27875 (QIU11_27875) 5859226..5859558 + 333 WP_058177536.1 hypothetical protein -
QIU11_RS27880 (QIU11_27880) 5859620..5860432 + 813 WP_071550097.1 hypothetical protein -
QIU11_RS27885 (QIU11_27885) 5860774..5861079 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
QIU11_RS27890 (QIU11_27890) 5861091..5861369 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QIU11_RS27895 (QIU11_27895) 5861422..5861550 - 129 Protein_5513 integrase -
QIU11_RS27900 (QIU11_27900) 5861698..5863926 + 2229 WP_003099265.1 TonB-dependent receptor -
QIU11_RS27905 (QIU11_27905) 5863996..5864643 - 648 WP_003095021.1 carbonate dehydratase -
QIU11_RS27910 (QIU11_27910) 5864705..5865943 - 1239 WP_023084819.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T280868 WP_003113526.1 NZ_CP124600:c5861369-5861091 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT280868 WP_003113527.1 NZ_CP124600:c5861079-5860774 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References