Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4624242..4625750 Replicon chromosome
Accession NZ_CP124600
Organism Pseudomonas aeruginosa strain Li010

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag QIU11_RS21940 Protein ID WP_003119682.1
Coordinates 4625163..4625750 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag QIU11_RS21935 Protein ID WP_003091607.1
Coordinates 4624242..4625096 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIU11_RS21920 (QIU11_21920) 4619661..4619870 + 210 WP_003115568.1 cold-shock protein -
QIU11_RS21925 (QIU11_21925) 4619931..4621805 - 1875 WP_003117607.1 MFS transporter -
QIU11_RS21930 (QIU11_21930) 4621980..4624145 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
QIU11_RS21935 (QIU11_21935) 4624242..4625096 - 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
QIU11_RS21940 (QIU11_21940) 4625163..4625750 - 588 WP_003119682.1 GNAT family protein Toxin
QIU11_RS21945 (QIU11_21945) 4626016..4629495 + 3480 WP_058177527.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T280866 WP_003119682.1 NZ_CP124600:c4625750-4625163 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT280866 WP_003091607.1 NZ_CP124600:c4625096-4624242 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References