Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2705091..2706312 Replicon chromosome
Accession NZ_CP124600
Organism Pseudomonas aeruginosa strain Li010

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QIU11_RS12975 Protein ID WP_003160088.1
Coordinates 2705091..2705669 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QIU11_RS12980 Protein ID WP_003088112.1
Coordinates 2705758..2706312 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIU11_RS12960 (QIU11_12960) 2700367..2701644 + 1278 WP_003102743.1 TolC family protein -
QIU11_RS12965 (QIU11_12965) 2701634..2703805 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
QIU11_RS12970 (QIU11_12970) 2703795..2704982 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
QIU11_RS12975 (QIU11_12975) 2705091..2705669 - 579 WP_003160088.1 HD domain-containing protein Toxin
QIU11_RS12980 (QIU11_12980) 2705758..2706312 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
QIU11_RS12985 (QIU11_12985) 2706470..2708665 - 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QIU11_RS12990 (QIU11_12990) 2708670..2709131 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
QIU11_RS12995 (QIU11_12995) 2709462..2709785 + 324 WP_003102734.1 multidrug efflux SMR transporter -
QIU11_RS13000 (QIU11_13000) 2709798..2710196 + 399 WP_023081774.1 NADH-quinone oxidoreductase subunit A -
QIU11_RS13005 (QIU11_13005) 2710193..2710744 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T280864 WP_003160088.1 NZ_CP124600:c2705669-2705091 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT280864 WP_003088112.1 NZ_CP124600:c2706312-2705758 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References