Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1756307..1757565 Replicon chromosome
Accession NZ_CP124600
Organism Pseudomonas aeruginosa strain Li010

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QIU11_RS08510 Protein ID WP_033866980.1
Coordinates 1756810..1757565 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QIU11_RS08505 Protein ID WP_003086329.1
Coordinates 1756307..1756675 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QIU11_RS08480 (QIU11_08480) 1752426..1752560 - 135 WP_256714168.1 hypothetical protein -
QIU11_RS08485 (QIU11_08485) 1752585..1752740 + 156 WP_003086320.1 zinc ribbon domain-containing protein -
QIU11_RS08490 (QIU11_08490) 1752743..1753219 - 477 WP_003140638.1 hypothetical protein -
QIU11_RS08495 (QIU11_08495) 1753394..1754889 + 1496 Protein_1674 aldehyde dehydrogenase family protein -
QIU11_RS08500 (QIU11_08500) 1754945..1756234 + 1290 WP_070163865.1 FAD-binding oxidoreductase -
QIU11_RS08505 (QIU11_08505) 1756307..1756675 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QIU11_RS08510 (QIU11_08510) 1756810..1757565 + 756 WP_033866980.1 RES family NAD+ phosphorylase Toxin
QIU11_RS08515 (QIU11_08515) 1758333..1759694 + 1362 WP_079862734.1 DNA recombination protein RmuC -
QIU11_RS08520 (QIU11_08520) 1759849..1762391 - 2543 Protein_1679 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28298.46 Da        Isoelectric Point: 8.0527

>T280863 WP_033866980.1 NZ_CP124600:1756810-1757565 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVYTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT280863 WP_003086329.1 NZ_CP124600:1756307-1756675 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References