Detailed information of TA system TA280773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3814899..3816588
• Replicon: chromosome
• Accession: NZ_CP124515
• Organism: Escherichia coli strain AVS0282

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP70_RS18670
• Protein ID: WP_000365807.1
• Coordinates: 3814899..3815819 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP70_RS18675
• Protein ID: WP_001295795.1
• Coordinates: 3815806..3816588 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP70_RS18630 (3810372)	3810372..3811082	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
QJP70_RS18635 (3811389)	3811389..3811718	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP70_RS18640 (3811730)	3811730..3811896	-	167	Protein_3660	tail fiber assembly protein	-
QJP70_RS18645 (3811967)	3811967..3812581	-	615	WP_001019923.1	YagU family protein	-
QJP70_RS18650 (3812796)	3812796..3812981	-	186	WP_000146240.1	hypothetical protein	-
QJP70_RS18655 (3813030)	3813030..3813188	+	159	Protein_3663	integrase	-
QJP70_RS18660 (3813415)	3813415..3813750	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP70_RS18665 (3813958)	3813958..3814734	+	777	WP_000171155.1	site-specific integrase	-
QJP70_RS18670 (3814899)	3814899..3815819	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP70_RS18675 (3815806)	3815806..3816588	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP70_RS18680 (3816872)	3816872..3819970	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3773909..3823651	49742

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280773 WP_000365807.1 NZ_CP124515:c3815819-3814899 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280773 WP_001295795.1 NZ_CP124515:c3816588-3815806 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0