Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2010355..2010857 Replicon chromosome
Accession NZ_CP124515
Organism Escherichia coli strain AVS0282

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag QJP70_RS09580 Protein ID WP_000767822.1
Coordinates 2010603..2010857 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QJP70_RS09575 Protein ID WP_001259255.1
Coordinates 2010355..2010606 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP70_RS09550 (2005533) 2005533..2006600 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QJP70_RS09555 (2006600) 2006600..2007670 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QJP70_RS09560 (2007667) 2007667..2008971 - 1305 WP_001546022.1 histidinol dehydrogenase -
QJP70_RS09565 (2008977) 2008977..2009876 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QJP70_RS09570 (2010022) 2010022..2010072 - 51 WP_001364200.1 his operon leader peptide -
QJP70_RS09575 (2010355) 2010355..2010606 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QJP70_RS09580 (2010603) 2010603..2010857 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QJP70_RS09585 (2010940) 2010940..2011764 + 825 WP_000754737.1 SDR family oxidoreductase -
QJP70_RS09590 (2011810) 2011810..2012739 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QJP70_RS09595 (2012954) 2012954..2013016 + 63 WP_010723108.1 membrane protein YoeI -
QJP70_RS09600 (2013006) 2013006..2014364 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T280763 WP_000767822.1 NZ_CP124515:2010603-2010857 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT280763 WP_001259255.1 NZ_CP124515:2010355-2010606 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References