280523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2941972..2942443 Replicon chromosome
Accession NZ_CP124487
Organism Escherichia coli strain AVS0542

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP68_RS14455 Protein ID WP_001303511.1
Coordinates 2942165..2942443 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP68_RS14450 Protein ID WP_001302048.1
Coordinates 2941972..2942163 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP68_RS14405 (2937221) 2937221..2937439 - 219 WP_001610644.1 DUF4014 family protein -
QJP68_RS14410 (2937472) 2937472..2937684 - 213 WP_000072553.1 hypothetical protein -
QJP68_RS14415 (2937790) 2937790..2938212 - 423 Protein_2834 DUF977 family protein -
QJP68_RS14420 (2938228) 2938228..2938998 - 771 WP_000450998.1 DUF1627 domain-containing protein -
QJP68_RS14425 (2939020) 2939020..2939766 - 747 WP_000788950.1 ATP-binding protein -
QJP68_RS14430 (2939773) 2939773..2940735 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP68_RS14435 (2940758) 2940758..2941183 - 426 WP_000693943.1 toxin YdaT family protein -
QJP68_RS14440 (2941180) 2941180..2941482 - 303 WP_001556930.1 transcriptional regulator -
QJP68_RS14445 (2941580) 2941580..2941951 + 372 WP_001169687.1 hypothetical protein -
QJP68_RS14450 (2941972) 2941972..2942163 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP68_RS14455 (2942165) 2942165..2942443 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP68_RS14460 (2942734) 2942734..2942886 + 153 WP_000380313.1 DUF1391 family protein -
QJP68_RS14465 (2942898) 2942898..2943236 + 339 WP_000394541.1 hypothetical protein -
QJP68_RS14470 (2943225) 2943225..2943419 - 195 WP_001295058.1 hypothetical protein -
QJP68_RS14475 (2943995) 2943995..2944183 + 189 WP_000449175.1 cell division inhibition protein DicB -
QJP68_RS14480 (2944180) 2944180..2944368 + 189 WP_000199475.1 DUF1482 family protein -
QJP68_RS14485 (2944461) 2944461..2946899 + 2439 WP_000102132.1 exonuclease -
QJP68_RS14490 (2946961) 2946961..2947230 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2895483..2955485 60002
- inside Prophage - - 2894313..2955485 61172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T280523 WP_001303511.1 NZ_CP124487:2942165-2942443 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT280523 WP_001302048.1 NZ_CP124487:2941972-2942163 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
AlphaFold DB A0A829CTP0

References