Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3910639..3911293 Replicon chromosome
Accession NZ_CP124455
Organism Escherichia coli strain AVS0193

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag QJP76_RS19210 Protein ID WP_000244765.1
Coordinates 3910639..3911046 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag QJP76_RS19215 Protein ID WP_000354050.1
Coordinates 3911027..3911293 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP76_RS19190 (3906596) 3906596..3908329 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
QJP76_RS19195 (3908335) 3908335..3909045 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJP76_RS19200 (3909070) 3909070..3909966 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QJP76_RS19205 (3910078) 3910078..3910599 + 522 WP_001055874.1 flavodoxin FldB -
QJP76_RS19210 (3910639) 3910639..3911046 - 408 WP_000244765.1 protein YgfX Toxin
QJP76_RS19215 (3911027) 3911027..3911293 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
QJP76_RS19220 (3911536) 3911536..3912516 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
QJP76_RS19225 (3912593) 3912593..3913252 - 660 WP_000250275.1 hemolysin III family protein -
QJP76_RS19230 (3913416) 3913416..3913727 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
QJP76_RS19235 (3913772) 3913772..3915205 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T280330 WP_000244765.1 NZ_CP124455:c3911046-3910639 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT280330 WP_000354050.1 NZ_CP124455:c3911293-3911027 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References