Detailed information of TA system TA280217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 968679..970368
• Replicon: chromosome
• Accession: NZ_CP124429
• Organism: Escherichia coli strain AVS0051

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP74_RS04600
• Protein ID: WP_000365807.1
• Coordinates: 969448..970368 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP74_RS04595
• Protein ID: WP_001295795.1
• Coordinates: 968679..969461 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP74_RS04590 (965297)	965297..968395	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP74_RS04595 (968679)	968679..969461	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP74_RS04600 (969448)	969448..970368	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP74_RS04605 (970533)	970533..971309	-	777	WP_000171155.1	site-specific integrase	-
QJP74_RS04610 (971517)	971517..971852	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP74_RS04615 (972079)	972079..972237	-	159	Protein_895	integrase	-
QJP74_RS04620 (972286)	972286..972471	+	186	WP_000146240.1	hypothetical protein	-
QJP74_RS04625 (972686)	972686..973300	+	615	WP_001019923.1	YagU family protein	-
QJP74_RS04630 (973371)	973371..973537	+	167	Protein_898	tail fiber assembly protein	-
QJP74_RS04635 (973549)	973549..973878	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP74_RS04640 (974185)	974185..974895	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	962429..1000725	38296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280217 WP_000365807.1 NZ_CP124429:969448-970368 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280217 WP_001295795.1 NZ_CP124429:968679-969461 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0