Detailed information of TA system TA280096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3889616..3891305
• Replicon: chromosome
• Accession: NZ_CP124410
• Organism: Escherichia coli strain AVS0543

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: QJP61_RS18735
• Protein ID: WP_000365807.1
• Coordinates: 3890385..3891305 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QJP61_RS18730
• Protein ID: WP_001295795.1
• Coordinates: 3889616..3890398 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJP61_RS18725 (3886234)	3886234..3889332	-	3099	WP_000673070.1	type I restriction endonuclease	-
QJP61_RS18730 (3889616)	3889616..3890398	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QJP61_RS18735 (3890385)	3890385..3891305	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJP61_RS18740 (3891470)	3891470..3892246	-	777	WP_000171155.1	site-specific integrase	-
QJP61_RS18745 (3892454)	3892454..3892789	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
QJP61_RS18750 (3893016)	3893016..3893174	-	159	Protein_3666	integrase	-
QJP61_RS18755 (3893223)	3893223..3893408	+	186	WP_000146240.1	hypothetical protein	-
QJP61_RS18760 (3893623)	3893623..3894237	+	615	WP_001019923.1	YagU family protein	-
QJP61_RS18765 (3894308)	3894308..3894474	+	167	Protein_3669	tail fiber assembly protein	-
QJP61_RS18770 (3894486)	3894486..3894815	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
QJP61_RS18775 (3895122)	3895122..3895832	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3883366..3931521	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T280096 WP_000365807.1 NZ_CP124410:3890385-3891305 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT280096 WP_001295795.1 NZ_CP124410:3889616-3890398 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0