Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3330910..3331505 Replicon chromosome
Accession NZ_CP124410
Organism Escherichia coli strain AVS0543

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QJP61_RS16010 Protein ID WP_000239579.1
Coordinates 3331155..3331505 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QJP61_RS16005 Protein ID WP_001223208.1
Coordinates 3330910..3331161 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP61_RS15995 (3326575) 3326575..3330354 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
QJP61_RS16000 (3330357) 3330357..3330698 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QJP61_RS16005 (3330910) 3330910..3331161 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QJP61_RS16010 (3331155) 3331155..3331505 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QJP61_RS16015 (3331585) 3331585..3332115 - 531 WP_000055075.1 inorganic diphosphatase -
QJP61_RS16020 (3332425) 3332425..3333381 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QJP61_RS16025 (3333521) 3333521..3335023 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
QJP61_RS16030 (3335037) 3335037..3336059 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T280092 WP_000239579.1 NZ_CP124410:3331155-3331505 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT280092 WP_001223208.1 NZ_CP124410:3330910-3331161 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References