Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2120312..2121111 Replicon chromosome
Accession NZ_CP124367
Organism Escherichia coli strain AVS0465

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QJP75_RS10320 Protein ID WP_000347251.1
Coordinates 2120647..2121111 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QJP75_RS10315 Protein ID WP_001296435.1
Coordinates 2120312..2120647 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP75_RS10300 (2116097) 2116097..2116867 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
QJP75_RS10305 (2116883) 2116883..2118217 - 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QJP75_RS10310 (2118592) 2118592..2120163 + 1572 WP_001273763.1 galactarate dehydratase -
QJP75_RS10315 (2120312) 2120312..2120647 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QJP75_RS10320 (2120647) 2120647..2121111 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QJP75_RS10325 (2121166) 2121166..2121975 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QJP75_RS10330 (2122224) 2122224..2123504 + 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
QJP75_RS10335 (2123527) 2123527..2124000 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QJP75_RS10340 (2124011) 2124011..2124790 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QJP75_RS10345 (2124780) 2124780..2125658 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QJP75_RS10350 (2125676) 2125676..2126110 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2111130..2121111 9981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T279859 WP_000347251.1 NZ_CP124367:2120647-2121111 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT279859 WP_001296435.1 NZ_CP124367:2120312-2120647 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References