Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2963097..2963568 Replicon chromosome
Accession NZ_CP124359
Organism Escherichia coli strain AVS0093

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP83_RS14605 Protein ID WP_001303511.1
Coordinates 2963290..2963568 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP83_RS14600 Protein ID WP_001302048.1
Coordinates 2963097..2963288 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP83_RS14530 (2958164) 2958164..2958331 - 168 WP_000207997.1 hypothetical protein -
QJP83_RS14535 (2958342) 2958342..2958605 - 264 WP_000224216.1 hypothetical protein -
QJP83_RS14540 (2958607) 2958607..2958825 - 219 WP_001142588.1 DUF4014 family protein -
QJP83_RS14545 (2958827) 2958827..2959042 - 216 WP_000510387.1 hypothetical protein -
QJP83_RS14550 (2959043) 2959043..2959402 - 360 WP_001289986.1 hypothetical protein -
QJP83_RS14555 (2959399) 2959399..2959575 - 177 WP_021534704.1 hypothetical protein -
QJP83_RS14560 (2959568) 2959568..2959750 - 183 WP_001224665.1 hypothetical protein -
QJP83_RS14565 (2959879) 2959879..2960190 - 312 WP_021534703.1 hypothetical protein -
QJP83_RS14570 (2960183) 2960183..2960437 - 255 WP_000004322.1 hypothetical protein -
QJP83_RS14575 (2960434) 2960434..2960856 - 423 WP_021534702.1 DUF977 family protein -
QJP83_RS14580 (2960897) 2960897..2961859 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP83_RS14585 (2961882) 2961882..2962307 - 426 WP_000693943.1 toxin YdaT family protein -
QJP83_RS14590 (2962304) 2962304..2962606 - 303 WP_000172738.1 transcriptional regulator -
QJP83_RS14595 (2962705) 2962705..2963076 + 372 WP_001169687.1 hypothetical protein -
QJP83_RS14600 (2963097) 2963097..2963288 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP83_RS14605 (2963290) 2963290..2963568 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP83_RS14610 (2963860) 2963860..2964012 + 153 WP_000380313.1 DUF1391 family protein -
QJP83_RS14615 (2964024) 2964024..2964362 + 339 WP_000394541.1 hypothetical protein -
QJP83_RS14620 (2964351) 2964351..2964545 - 195 WP_001295058.1 hypothetical protein -
QJP83_RS14625 (2965112) 2965112..2965300 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP83_RS14630 (2965297) 2965297..2965485 + 189 WP_000199480.1 DUF1482 family protein -
QJP83_RS14635 (2965581) 2965581..2968052 + 2472 WP_032284123.1 exonuclease -
QJP83_RS14640 (2968114) 2968114..2968383 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2944870..2972778 27908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279840 WP_001303511.1 NZ_CP124359:2963290-2963568 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279840 WP_001302048.1 NZ_CP124359:2963097-2963288 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References