Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 94422..94947 Replicon plasmid pAVS0453-A
Accession NZ_CP124350
Organism Escherichia coli strain AVS0453

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag QJP64_RS26765 Protein ID WP_001159871.1
Coordinates 94422..94727 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag QJP64_RS26770 Protein ID WP_000813630.1
Coordinates 94729..94947 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP64_RS26750 (90384) 90384..91550 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
QJP64_RS26755 (92138) 92138..92893 - 756 WP_000852146.1 replication initiation protein RepE -
QJP64_RS26760 (93615) 93615..94421 - 807 WP_000016970.1 site-specific integrase -
QJP64_RS26765 (94422) 94422..94727 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
QJP64_RS26770 (94729) 94729..94947 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
QJP64_RS26775 (95507) 95507..95737 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
QJP64_RS26780 (95734) 95734..96150 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
QJP64_RS26785 (96225) 96225..97790 + 1566 WP_001128474.1 AAA family ATPase -
QJP64_RS26790 (97775) 97775..98797 + 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iutA / iucD 1..105823 105823


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T279698 WP_001159871.1 NZ_CP124350:c94727-94422 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT279698 WP_000813630.1 NZ_CP124350:c94947-94729 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References