Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2964639..2965110 Replicon chromosome
Accession NZ_CP124345
Organism Escherichia coli strain AVS0530

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP77_RS14595 Protein ID WP_001303511.1
Coordinates 2964832..2965110 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP77_RS14590 Protein ID WP_001302048.1
Coordinates 2964639..2964830 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP77_RS14520 (2959706) 2959706..2959873 - 168 WP_000207997.1 hypothetical protein -
QJP77_RS14525 (2959884) 2959884..2960147 - 264 WP_000224216.1 hypothetical protein -
QJP77_RS14530 (2960149) 2960149..2960367 - 219 WP_001142588.1 DUF4014 family protein -
QJP77_RS14535 (2960369) 2960369..2960584 - 216 WP_000510387.1 hypothetical protein -
QJP77_RS14540 (2960585) 2960585..2960944 - 360 WP_001289986.1 hypothetical protein -
QJP77_RS14545 (2960941) 2960941..2961117 - 177 WP_021534704.1 hypothetical protein -
QJP77_RS14550 (2961110) 2961110..2961292 - 183 WP_001224665.1 hypothetical protein -
QJP77_RS14555 (2961421) 2961421..2961732 - 312 WP_021534703.1 hypothetical protein -
QJP77_RS14560 (2961725) 2961725..2961979 - 255 WP_000004322.1 hypothetical protein -
QJP77_RS14565 (2961976) 2961976..2962398 - 423 WP_021534702.1 DUF977 family protein -
QJP77_RS14570 (2962439) 2962439..2963401 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP77_RS14575 (2963424) 2963424..2963849 - 426 WP_000693943.1 toxin YdaT family protein -
QJP77_RS14580 (2963846) 2963846..2964148 - 303 WP_000172738.1 transcriptional regulator -
QJP77_RS14585 (2964247) 2964247..2964618 + 372 WP_001169687.1 hypothetical protein -
QJP77_RS14590 (2964639) 2964639..2964830 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP77_RS14595 (2964832) 2964832..2965110 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP77_RS14600 (2965402) 2965402..2965554 + 153 WP_000380313.1 DUF1391 family protein -
QJP77_RS14605 (2965566) 2965566..2965904 + 339 WP_000394541.1 hypothetical protein -
QJP77_RS14610 (2965893) 2965893..2966087 - 195 WP_001295058.1 hypothetical protein -
QJP77_RS14615 (2966654) 2966654..2966842 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP77_RS14620 (2966839) 2966839..2967027 + 189 WP_000199480.1 DUF1482 family protein -
QJP77_RS14625 (2967123) 2967123..2969594 + 2472 WP_032284123.1 exonuclease -
QJP77_RS14630 (2969656) 2969656..2969925 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage sitABCD - 2857403..2978180 120777
- inside Prophage sitABCD - 2829559..2978180 148621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279634 WP_001303511.1 NZ_CP124345:2964832-2965110 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279634 WP_001302048.1 NZ_CP124345:2964639-2964830 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References