Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2964763..2965234 Replicon chromosome
Accession NZ_CP124343
Organism Escherichia coli strain AVS0533

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QJP85_RS14610 Protein ID WP_001303511.1
Coordinates 2964956..2965234 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QJP85_RS14605 Protein ID WP_001302048.1
Coordinates 2964763..2964954 (+) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJP85_RS14535 (2959830) 2959830..2959997 - 168 WP_000207997.1 hypothetical protein -
QJP85_RS14540 (2960008) 2960008..2960271 - 264 WP_000224216.1 hypothetical protein -
QJP85_RS14545 (2960273) 2960273..2960491 - 219 WP_001142588.1 DUF4014 family protein -
QJP85_RS14550 (2960493) 2960493..2960708 - 216 WP_000510387.1 hypothetical protein -
QJP85_RS14555 (2960709) 2960709..2961068 - 360 WP_001289986.1 hypothetical protein -
QJP85_RS14560 (2961065) 2961065..2961241 - 177 WP_021534704.1 hypothetical protein -
QJP85_RS14565 (2961234) 2961234..2961416 - 183 WP_001224665.1 hypothetical protein -
QJP85_RS14570 (2961545) 2961545..2961856 - 312 WP_021534703.1 hypothetical protein -
QJP85_RS14575 (2961849) 2961849..2962103 - 255 WP_000004322.1 hypothetical protein -
QJP85_RS14580 (2962100) 2962100..2962522 - 423 WP_021534702.1 DUF977 family protein -
QJP85_RS14585 (2962563) 2962563..2963525 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
QJP85_RS14590 (2963548) 2963548..2963973 - 426 WP_000693943.1 toxin YdaT family protein -
QJP85_RS14595 (2963970) 2963970..2964272 - 303 WP_000172738.1 transcriptional regulator -
QJP85_RS14600 (2964371) 2964371..2964742 + 372 WP_001169687.1 hypothetical protein -
QJP85_RS14605 (2964763) 2964763..2964954 + 192 WP_001302048.1 hypothetical protein Antitoxin
QJP85_RS14610 (2964956) 2964956..2965234 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJP85_RS14615 (2965526) 2965526..2965678 + 153 WP_000380313.1 DUF1391 family protein -
QJP85_RS14620 (2965690) 2965690..2966028 + 339 WP_000394541.1 hypothetical protein -
QJP85_RS14625 (2966017) 2966017..2966211 - 195 WP_001295058.1 hypothetical protein -
QJP85_RS14630 (2966778) 2966778..2966966 + 189 WP_000449172.1 cell division inhibition protein DicB -
QJP85_RS14635 (2966963) 2966963..2967151 + 189 WP_000199480.1 DUF1482 family protein -
QJP85_RS14640 (2967247) 2967247..2969718 + 2472 WP_032284123.1 exonuclease -
QJP85_RS14645 (2969780) 2969780..2970049 + 270 WP_000003742.1 excisionase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage sitABCD - 2857527..2978304 120777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T279612 WP_001303511.1 NZ_CP124343:2964956-2965234 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp


Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT279612 WP_001302048.1 NZ_CP124343:2964763-2964954 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE


Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References