Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 6217101..6217736 Replicon chromosome
Accession NZ_CP124222
Organism Paenibacillus dendritiformis strain 2022CK-00834

Toxin (Protein)


Gene name pemK Uniprot ID H3SI32
Locus tag QJQ58_RS27685 Protein ID WP_006677694.1
Coordinates 6217386..6217736 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W4HCL7
Locus tag QJQ58_RS27680 Protein ID WP_040731899.1
Coordinates 6217101..6217382 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ58_RS27670 (QJQ58_27670) 6214297..6215415 + 1119 WP_281475880.1 DUF4367 domain-containing protein -
QJQ58_RS27675 (QJQ58_27675) 6215657..6216883 + 1227 WP_281475882.1 alanine racemase -
QJQ58_RS27680 (QJQ58_27680) 6217101..6217382 + 282 WP_040731899.1 CopG family ribbon-helix-helix protein Antitoxin
QJQ58_RS27685 (QJQ58_27685) 6217386..6217736 + 351 WP_006677694.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QJQ58_RS27690 (QJQ58_27690) 6218390..6220861 - 2472 WP_281475887.1 M60 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12843.83 Da        Isoelectric Point: 5.5664

>T279345 WP_006677694.1 NZ_CP124222:6217386-6217736 [Paenibacillus dendritiformis]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMHKVDDGLLISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10735.45 Da        Isoelectric Point: 8.4934

>AT279345 WP_040731899.1 NZ_CP124222:6217101-6217382 [Paenibacillus dendritiformis]
VANIQNTKRIMISLPDQLLQEVDGIVAMEKSNRSEFIRQAMKLYLQERKKRHIRESMQRGYMEMAKINLTMASEAFYAEV
EADGTLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3SI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2W4HCL7

References