Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 76039..76651 Replicon plasmid pLX02
Accession NZ_CP123976
Organism Thioclava nitratireducens strain M1-LQ-LJL-11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P0N61_RS20595 Protein ID WP_088726100.1
Coordinates 76256..76651 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1M7KKN2
Locus tag P0N61_RS20590 Protein ID WP_009815510.1
Coordinates 76039..76266 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0N61_RS20575 (P0N61_20575) 71646..72962 - 1317 WP_088726103.1 plasmid replication protein RepC -
P0N61_RS20580 (P0N61_20580) 73182..74129 - 948 WP_240504181.1 plasmid partitioning protein RepB -
P0N61_RS20585 (P0N61_20585) 74153..75337 - 1185 WP_088726101.1 plasmid partitioning protein RepA -
P0N61_RS20590 (P0N61_20590) 76039..76266 + 228 WP_009815510.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P0N61_RS20595 (P0N61_20595) 76256..76651 + 396 WP_088726100.1 PIN domain-containing protein Toxin
P0N61_RS20600 (P0N61_20600) 76635..77357 - 723 Protein_82 recombinase family protein -
P0N61_RS20605 (P0N61_20605) 77505..79139 + 1635 WP_024099411.1 Mu transposase C-terminal domain-containing protein -
P0N61_RS20610 (P0N61_20610) 79141..80022 + 882 WP_024099410.1 TniB family NTP-binding protein -
P0N61_RS20615 (P0N61_20615) 80019..80810 + 792 WP_007803196.1 TniQ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..131650 131650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-115)

Antitoxin

Antitoxin PemI-like

(2-46)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14335.29 Da        Isoelectric Point: 4.2057

>T279295 WP_088726100.1 NZ_CP123976:76256-76651 [Thioclava nitratireducens]
MSAEFADTNVVLYLLDDGAKAERAEEILGQGPRVSVQVLNETMVNCRRKAGLSWEDTGAILEAIQSLCPVEDLTVQTHQV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWTEDTHDGLLVEDRLRIVNPFA

Download         Length: 396 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.78 Da        Isoelectric Point: 10.8838

>AT279295 WP_009815510.1 NZ_CP123976:76039-76266 [Thioclava nitratireducens]
MQVAKWGNSLAVRLPADLVRELGLKEGDQVDLVKDDGTILVRRQPRADEVLQGLRRFRGKLPKDARLSRDAAHER

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1M7KKN2

References