279236

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3005318..3005820 Replicon chromosome
Accession NZ_CP123951
Organism Escherichia coli strain TL012

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QGM68_RS14275 Protein ID WP_000767829.1
Coordinates 3005566..3005820 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QGM68_RS14270 Protein ID WP_001259255.1
Coordinates 3005318..3005569 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QGM68_RS14245 (3000496) 3000496..3001563 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QGM68_RS14250 (3001563) 3001563..3002633 - 1071 WP_001468894.1 histidinol-phosphate transaminase -
QGM68_RS14255 (3002630) 3002630..3003934 - 1305 WP_032214175.1 histidinol dehydrogenase -
QGM68_RS14260 (3003940) 3003940..3004839 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QGM68_RS14265 (3004985) 3004985..3005035 - 51 WP_001364200.1 his operon leader peptide -
QGM68_RS14270 (3005318) 3005318..3005569 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QGM68_RS14275 (3005566) 3005566..3005820 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QGM68_RS14280 (3005903) 3005903..3006727 + 825 WP_000754749.1 SDR family oxidoreductase -
QGM68_RS14285 (3006773) 3006773..3007702 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QGM68_RS14290 (3007917) 3007917..3007979 + 63 WP_010723108.1 membrane protein YoeI -
QGM68_RS14295 (3007969) 3007969..3009327 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QGM68_RS14300 (3009506) 3009506..3010564 + 1059 WP_053276361.1 thiosulfate utilization transporter TsuA/YeeE -
QGM68_RS14305 (3010578) 3010578..3010805 + 228 WP_000985280.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T279236 WP_000767829.1 NZ_CP123951:3005566-3005820 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT279236 WP_001259255.1 NZ_CP123951:3005318-3005569 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References