Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 123115..123891 Replicon chromosome
Accession NZ_CP123853
Organism Staphylococcus aureus strain FDA209P

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NUG19_RS00775 Protein ID WP_000031108.1
Coordinates 123739..123891 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NUG19_RS00770 Protein ID WP_001251224.1
Coordinates 123115..123714 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG19_RS00750 (119030) 119030..120487 + 1458 WP_000649907.1 ABC transporter permease subunit -
NUG19_RS00755 (120480) 120480..121202 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NUG19_RS00760 (121354) 121354..122481 + 1128 WP_258239600.1 tRNA epoxyqueuosine(34) reductase QueG -
NUG19_RS00765 (122486) 122486..122956 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NUG19_RS00770 (123115) 123115..123714 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NUG19_RS00775 (123739) 123739..123891 + 153 WP_000031108.1 SAS053 family protein Toxin
NUG19_RS00780 (124435) 124435..124830 + 396 WP_000901023.1 hypothetical protein -
NUG19_RS00785 (125026) 125026..126411 + 1386 WP_000116229.1 class II fumarate hydratase -
NUG19_RS00790 (126863) 126863..127684 - 822 WP_042727629.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 117412..118731 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T279182 WP_000031108.1 NZ_CP123853:123739-123891 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT279182 WP_001251224.1 NZ_CP123853:123115-123714 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References