Detailed information of TA system TA279105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3648868..3650549
• Replicon: chromosome
• Accession: NZ_CP123642
• Organism: Klebsiella pneumoniae strain KpBSB53

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486TL08
• Locus tag: QFW99_RS18570
• Protein ID: WP_032417722.1
• Coordinates: 3648868..3649785 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: QFW99_RS18575
• Protein ID: WP_004177809.1
• Coordinates: 3649791..3650549 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QFW99_RS18550 (3644174)	3644174..3645694	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
QFW99_RS18555 (3645691)	3645691..3646689	+	999	WP_032417724.1	COG4158 family protein	-
QFW99_RS18560 (3646720)	3646720..3647661	+	942	WP_032417723.1	ABC transporter substrate-binding protein	-
QFW99_RS18565 (3647736)	3647736..3648743	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
QFW99_RS18570 (3648868)	3648868..3649785	-	918	WP_032417722.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QFW99_RS18575 (3649791)	3649791..3650549	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
QFW99_RS18580 (3650635)	3650635..3651363	-	729	WP_004177810.1	response regulator transcription factor	-
QFW99_RS18585 (3651636)	3651636..3653783	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
QFW99_RS18590 (3654013)	3654013..3654699	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34674.07 Da
• Isoelectric Point: 5.4707

>T279105 WP_032417722.1 NZ_CP123642:c3649785-3648868 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPQESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT279105 WP_004177809.1 NZ_CP123642:c3650549-3649791 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A0A486TL08

Antitoxin

• AlphaFold DB: A6TH05