Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3747540..3748270 Replicon chromosome
Accession NZ_CP123597
Organism Serratia marcescens strain RMCH-M26-N

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0QJB7
Locus tag QFB82_RS18040 Protein ID WP_060560355.1
Coordinates 3747540..3747851 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QFB82_RS18045 Protein ID WP_004937031.1
Coordinates 3747848..3748270 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB82_RS18010 (QFB82_18010) 3742867..3743592 + 726 WP_004937040.1 LPS export ABC transporter ATP-binding protein -
QFB82_RS18015 (QFB82_18015) 3743645..3745078 + 1434 WP_021505109.1 RNA polymerase factor sigma-54 -
QFB82_RS18020 (QFB82_18020) 3745102..3745389 + 288 WP_004937038.1 ribosome hibernation promoting factor -
QFB82_RS18025 (QFB82_18025) 3745545..3746006 + 462 WP_016930212.1 PTS IIA-like nitrogen regulatory protein PtsN -
QFB82_RS18030 (QFB82_18030) 3746134..3746988 + 855 WP_015379177.1 RNase adapter RapZ -
QFB82_RS18035 (QFB82_18035) 3746985..3747257 + 273 WP_004937034.1 PTS phosphocarrier protein NPr -
QFB82_RS18040 (QFB82_18040) 3747540..3747851 + 312 WP_060560355.1 type II toxin-antitoxin system HigB family toxin Toxin
QFB82_RS18045 (QFB82_18045) 3747848..3748270 + 423 WP_004937031.1 helix-turn-helix domain-containing protein Antitoxin
QFB82_RS18050 (QFB82_18050) 3748274..3750190 - 1917 WP_015379179.1 PRD domain-containing protein -
QFB82_RS18055 (QFB82_18055) 3750242..3751456 - 1215 WP_280597708.1 lactonase family protein -
QFB82_RS18060 (QFB82_18060) 3751544..3752284 - 741 WP_033632010.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(81-135)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12331.22 Da        Isoelectric Point: 10.0957

>T279060 WP_060560355.1 NZ_CP123597:3747540-3747851 [Serratia marcescens]
MHIISREPFNNATKQYPNEATALEAIYKALRRVEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Download         Length: 312 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15784.13 Da        Isoelectric Point: 5.2139

>AT279060 WP_004937031.1 NZ_CP123597:3747848-3748270 [Serratia marcescens]
MITDAIKAADALLRAVPLLQGSRAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQHIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0QJB7

Antitoxin

Source ID Structure

References