Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 797304..797851 Replicon chromosome
Accession NZ_CP123597
Organism Serratia marcescens strain RMCH-M26-N

Toxin (Protein)


Gene name ccdB Uniprot ID A0A086G3V8
Locus tag QFB82_RS04100 Protein ID WP_033633716.1
Coordinates 797543..797851 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0G3SUU9
Locus tag QFB82_RS04095 Protein ID WP_033633717.1
Coordinates 797304..797540 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB82_RS04080 (QFB82_04080) 793790..795325 + 1536 WP_060559031.1 glutathione ABC transporter substrate-binding protein GsiB -
QFB82_RS04085 (QFB82_04085) 795378..796298 + 921 WP_060559032.1 glutathione ABC transporter permease GsiC -
QFB82_RS04090 (QFB82_04090) 796308..797216 + 909 WP_019454428.1 glutathione ABC transporter permease GsiD -
QFB82_RS04095 (QFB82_04095) 797304..797540 + 237 WP_033633717.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QFB82_RS04100 (QFB82_04100) 797543..797851 + 309 WP_033633716.1 CcdB family protein Toxin
QFB82_RS04105 (QFB82_04105) 797888..798730 - 843 WP_015377214.1 S-formylglutathione hydrolase -
QFB82_RS04110 (QFB82_04110) 798745..799869 - 1125 WP_015377215.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
QFB82_RS04115 (QFB82_04115) 799899..800819 - 921 WP_280598107.1 LysR substrate-binding domain-containing protein -
QFB82_RS04120 (QFB82_04120) 800925..802082 + 1158 WP_031299819.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11448.21 Da        Isoelectric Point: 5.0196

>T279050 WP_033633716.1 NZ_CP123597:797543-797851 [Serratia marcescens]
MQFTVYDNTYPASAYPYLLDVQSDLIDALSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQLGKA
VGNANEHRNQIKAAIDFLIDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8994.07 Da        Isoelectric Point: 5.0807

>AT279050 WP_033633717.1 NZ_CP123597:797304-797540 [Serratia marcescens]
MANNNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086G3V8

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SUU9

References