Detailed information of TA system TA278923

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 526385..527852
• Replicon: chromosome
• Accession: NZ_CP123294
• Organism: Mycoplasmopsis bovis strain 15DD0207

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: Q932V7
• Locus tag: QEP34_RS02285
• Protein ID: WP_041309184.1
• Coordinates: 526992..527852 (+)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: QEP34_RS02280
• Protein ID: WP_013456322.1
• Coordinates: 526385..526999 (+)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QEP34_RS02255	521676..522704	-	1029	WP_078086175.1	IS30-like element ISMbov1 family transposase	-
QEP34_RS02260	523477..523686	+	210	Protein_421	variable surface lipoprotein	-
QEP34_RS02265	523754..524971	+	1218	WP_280135711.1	IS3 family transposase	-
QEP34_RS02270	524928..525395	+	468	WP_280135712.1	hypothetical protein	-
QEP34_RS02275	525438..526202	-	765	WP_075270933.1	variable surface lipoprotein	-
QEP34_RS02280	526385..526999	+	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QEP34_RS02285	526992..527852	+	861	WP_041309184.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QEP34_RS02290	527972..528862	+	891	WP_075271150.1	variable surface lipoprotein	-
QEP34_RS02295	529047..529772	+	726	WP_013456472.1	variable surface lipoprotein	-
QEP34_RS02300	530154..531182	-	1029	WP_078086175.1	IS30-like element ISMbov1 family transposase	-
QEP34_RS02305	531560..531742	+	183	WP_235125612.1	helix-turn-helix domain-containing protein	-
QEP34_RS02310	531847..532485	+	639	WP_235125609.1	IS30 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	521676..522794	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33281.35 Da
• Isoelectric Point: 7.2878

>T278923 WP_041309184.1 NZ_CP123294:526992-527852 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Nucleotide

• Length: 861 bp

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT278923 WP_013456322.1 NZ_CP123294:526385-526999 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

Structures

Toxin

• AlphaFold DB: Q932V7

Antitoxin

• AlphaFold DB: Q934C3