Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2710580..2711361 Replicon chromosome
Accession NZ_CP123280
Organism Salmonella sp. SA17155

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag QEN30_RS13790 Protein ID WP_000626099.1
Coordinates 2710580..2711071 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag QEN30_RS13795 Protein ID WP_001110452.1
Coordinates 2711068..2711361 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN30_RS13750 (2705766) 2705766..2706008 - 243 WP_197603740.1 hypothetical protein -
QEN30_RS13755 (2706005) 2706005..2706361 - 357 WP_033567083.1 hypothetical protein -
QEN30_RS13760 (2706358) 2706358..2707230 - 873 WP_033567082.1 ParA family protein -
QEN30_RS13765 (2707421) 2707421..2707498 - 78 Protein_2690 helix-turn-helix domain-containing protein -
QEN30_RS13770 (2707589) 2707589..2707921 - 333 WP_001165471.1 MerR family transcriptional regulator -
QEN30_RS13775 (2707993) 2707993..2708370 + 378 WP_000916345.1 EthD family reductase -
QEN30_RS13780 (2709403) 2709403..2709477 + 75 Protein_2693 porin family protein -
QEN30_RS13785 (2709580) 2709580..2710332 + 753 WP_000842434.1 non-specific acid phosphatase -
QEN30_RS13790 (2710580) 2710580..2711071 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
QEN30_RS13795 (2711068) 2711068..2711361 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
QEN30_RS13800 (2711678) 2711678..2711899 + 222 WP_001576552.1 hypothetical protein -
QEN30_RS13805 (2712164) 2712164..2713039 + 876 WP_000921674.1 AraC family transcriptional regulator -
QEN30_RS13810 (2713036) 2713036..2713323 + 288 WP_001269916.1 transcriptional regulator RtsB -
QEN30_RS13815 (2713346) 2713346..2713561 + 216 WP_001595136.1 hypothetical protein -
QEN30_RS13820 (2713569) 2713569..2713838 + 270 WP_010989096.1 hypothetical protein -
QEN30_RS13825 (2714132) 2714132..2715037 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T278887 WP_000626099.1 NZ_CP123280:c2711071-2710580 [Salmonella sp. SA17155]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT278887 WP_001110452.1 NZ_CP123280:c2711361-2711068 [Salmonella sp. SA17155]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References