Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 78995..79248 Replicon plasmid pYZMc17-1_NDM-5_80K
Accession NZ_CP123257
Organism Escherichia coli strain YZMc17-1

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag N4680_RS24525 Protein ID WP_001312851.1
Coordinates 79099..79248 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 78995..79054 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4680_RS24500 (75722) 75722..76468 + 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
N4680_RS24505 (76523) 76523..77083 + 561 WP_000139328.1 fertility inhibition protein FinO -
N4680_RS24510 (77215) 77215..77415 + 201 WP_015059022.1 hypothetical protein -
N4680_RS24515 (77801) 77801..78400 + 600 WP_032083981.1 PIN domain-containing protein -
N4680_RS24520 (78462) 78462..78794 + 333 WP_152916585.1 hypothetical protein -
- (78995) 78995..79054 - 60 NuclAT_1 - Antitoxin
- (78995) 78995..79054 - 60 NuclAT_1 - Antitoxin
- (78995) 78995..79054 - 60 NuclAT_1 - Antitoxin
- (78995) 78995..79054 - 60 NuclAT_1 - Antitoxin
N4680_RS24525 (79099) 79099..79248 + 150 WP_001312851.1 Hok/Gef family protein Toxin
N4680_RS24530 (79532) 79532..79780 + 249 WP_000083837.1 replication regulatory protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaNDM-5 / blaTEM-1B / rmtB - 1..80091 80091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T278817 WP_001312851.1 NZ_CP123257:79099-79248 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

Antitoxin


Download         Length: 60 bp

>AT278817 NZ_CP123257:c79054-78995 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References