Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 71216..71859 Replicon plasmid pMB11100_2
Accession NZ_CP123233
Organism Escherichia coli strain 5132

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag QET41_RS25240 Protein ID WP_001034044.1
Coordinates 71216..71632 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag QET41_RS25245 Protein ID WP_001261286.1
Coordinates 71629..71859 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QET41_RS25225 (QET41_25225) 67618..68315 + 698 WP_223155668.1 IS1-like element IS1A family transposase -
QET41_RS25230 (QET41_25230) 68569..69591 - 1023 WP_000361402.1 helicase UvrD -
QET41_RS25235 (QET41_25235) 69576..71141 - 1566 WP_001128474.1 AAA family ATPase -
QET41_RS25240 (QET41_25240) 71216..71632 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
QET41_RS25245 (QET41_25245) 71629..71859 - 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QET41_RS25250 (QET41_25250) 72240..76034 + 3795 WP_001144732.1 hypothetical protein -
QET41_RS25255 (QET41_25255) 76079..76495 - 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
QET41_RS25260 (QET41_25260) 76492..76722 - 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) senB 1..87114 87114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T278698 WP_001034044.1 NZ_CP123233:c71632-71216 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT278698 WP_001261286.1 NZ_CP123233:c71859-71629 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References